Key Findings

• Detransition rates ranged from 0.8-7.4% for treatment request shifts
• GnRHa discontinuation rates ranged from 1-7.6%
• GAHT discontinuation rates ranged from 1.6-9.8%
• 15 observational studies included with 7,074 participants
• Significant methodological heterogeneity across studies
• Long-term follow-up data is lacking

Abstract

Systematic review of 15 observational studies examining detransition prevalence among persons seeking gender-affirming hormonal treatments. Found rates ranged from 0.8-7.4% for treatment request shifts, 1-7.6% for GnRHa discontinuation, and 1.6-9.8% for GAHT discontinuation.

Summary

This systematic review found that detransition rates range from roughly 1-10% depending on the measure used, but methodological limitations make precise estimates difficult. The review highlights the need for better long-term follow-up studies.

Conclusion

Detransition rates vary widely across studies due to methodological differences, but the evidence suggests that a meaningful proportion of individuals discontinue or shift their treatment requests. Better long-term follow-up studies are needed.