Beyond NICE: Updated Systematic Review on the Current Evidence of Using Puberty Blocking Pharmacological Agents and Cross-Sex-Hormones in Minors with Gender Dysphoria
- Authors
- Zepf, B.D. et al.
- Year
- 2024
- Journal
- Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie
Key Findings
- Zero new puberty blocker studies met PICO criteria post-NICE
- Only 2 low-quality cross-sex hormone studies found
- Current evidence does not suggest GD symptoms improve with PB/CSH
- Evidence base remains methodologically weak
- Insufficient for reliable conclusions about benefits or long-term outcomes
Abstract
Updated systematic review examining evidence for puberty blockers and cross-sex hormones in minors, building on NICE reviews.
Summary
This review found that the evidence base for puberty blockers and cross-sex hormones in minors remains very weak, with no new high-quality studies since the NICE reviews.
Conclusion
The evidence base remains weak and insufficient to support reliable conclusions about benefits or long-term outcomes of puberty blockers and cross-sex hormones in minors.