Summary

WPATH's Standards of Care 8 (2022) is the world's most influential guideline for transgender healthcare. In this study, eight trained raters, doctors and therapists from several fields plus two experienced guideline experts, scored six chapters relevant to young people using the standard checklist for judging how well guidelines are made. The chapters scored poorly on rigour (how evidence was searched for, chosen and linked to advice), on practical usefulness and on independence from funders and conflicts. Overall quality was rated about 3.5 to 4 out of 7. Raters split evenly between recommending the chapters, recommending them with changes, and rejecting them. The findings echo the Cass Review's earlier rating. The study was funded by SEGM, and only eight raters took part.

Key findings

• Otto valutatori, un endocrinologo pediatrico, un chirurgo plastico, un pediatra, un medico di famiglia, uno psicologo, uno psichiatra e due esperti di linee guida, hanno ciascuno valutato in modo indipendente sei capitoli delle linee guida del WPATH.
• La cura nella sviluppo delle raccomandazioni ha ottenuto un punteggio del 39-47% tra i capitoli; le modalità di ricerca e selezione delle evidenze hanno ottenuto solo circa 1,5-2,5 su 7.
• L'utilità pratica ha totalizzato il punteggio più basso, 28-40%, con i piani per verificare l'applicazione delle raccomandazioni nella pratica valutati 1-1,5 su 7.
• L'indipendenza ha ottenuto il 43-44%, poiché non era chiaro come siano stati gestiti l'influenza dei finanziatori e i conflitti d'interesse.
• La qualità complessiva è stata valutata circa 3,5-4 su 7 per ogni capitolo (adolescenti, bambini, ormoni, salute mentale, cure del medico di famiglia e chirurgia).
• Solo due degli otto valutatori raccomanderebbero i capitoli senza modifiche; tre li raccomanderebbero con modifiche e tre non li raccomanderebbero.
• Finanziamento: lo studio è stato finanziato da SEGM, che secondo gli autori non ha avuto alcun ruolo nella sua progettazione, analisi o redazione. L'autore principale ha collaborato con SEGM, e a ogni clinico valutatore sono stati corrisposti 1.500 dollari USA per circa 30-40 ore di lavoro. Non sono dichiarati altri finanziamenti.

Abstract

In 2022, the World Professional Association for Transgender Health (WPATH) released their guidelines, Standards of Care Version 8 (SOC8), which have been regarded as establishing standards for the management of transgender patients. To conduct a quality assessment of the WPATH's SOC8 using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument, we recruited a diverse group of international health professionals as assessors, including six clinicians and two guideline methodologists, who were trained in the AGREE II tool and underwent a calibration exercise. They independently assessed six SOC8 chapters: adolescents, children, hormone therapy, mental health, primary care, and surgery. We summarized the ratings across assessors for all items to present the strengths and limitations of the guidelines. The evaluations identified that the SOC8 chapters had limitations in the AGREE II domains of applicability (ranging from 28% to 40% across chapters), editorial independence (ranging from 43% to 44% across chapters), and rigor of development (ranging from 39% to 47% across chapters). On a scale of 1 to 7 (7 = highest quality), the median overall quality score was 3.5 to 4 for all chapters. Two of eight assessors recommended using the guideline chapters, while three recommended use with modification, and three recommended not to use the reviewed guideline chapters due to methodological concerns. Evidence-based guidelines addressing the needs of transidentified people are urgently needed, but it is imperative that healthcare providers, researchers, and policymakers recognize and address the limitations present in these six SOC8 chapters.

Conclusion

The assessment found that WPATH's SOC8 guidelines have limitations in scientific and methodological rigour, applicability, and transparency in managing competing interests. Evidence-based guidelines addressing the needs of trans-identified children and adolescents are urgently needed, but uncritical adoption or endorsement of WPATH's guidelines may result in a disservice or even harm to this vulnerable population. Healthcare providers, researchers and policymakers should recognise and address the limitations of SOC8.