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Pregled Endocrine Society: malo kratkoročnih sprememb kostne gostote na hormonih, a skoraj nobenih podatkov o zlomih

Učinek spolnih steroidov na zdravje kosti pri transspolnih osebah: sistematični pregled in metaanaliza

Sistematični & evidenčni preglediKrižni spolni hormoni
Authors
Naykky Singh-Ospina, Spyridoula Maraka, Rene Rodriguez-Gutierrez, Caroline Davidge-Pitts, Todd B. Nippoldt, Larry J. Prokop, Mohammad Hassan Murad
Journal
The Journal of Clinical Endocrinology & Metabolism
Year
2017
Source
https://doi.org/10.1210/jc.2017-01642

Summary

This review was one of the evidence reviews behind the Endocrine Society's 2017 guideline on treating gender dysphoria (distress about one's sex). The Mayo Clinic team combined 13 studies (639 people, mostly adults) that measured bone density before and after cross-sex hormones. Testosterone in females made no measurable difference to spine or hip bone density over one to two years. Estrogen in males slightly raised spine bone density. Only one study looked at broken bones (none in a year), and only one looked at teenagers given puberty blockers (drugs that pause puberty) and then hormones. That study found males had lower spine bone density at age 22 than before treatment. The authors said the effect on the risk of broken bones is uncertain. The review is reassuring about short-term bone density in adults, but cannot show long-term safety, fracture risk, or safety for teenagers.

Key findings

  • Pregled je združil 13 študij, ki zajemajo 639 oseb: 392 rojenih kot moški in 247 rojenih kot ženske.
  • Pri ženskah, ki so jemale testosteron, se gostota kosti v spodnjem delu hrbtenice in kolku po enem ali dveh letih ni merljivo spremenila.
  • Pri moških, ki so jemali estrogen, se je gostota kosti v spodnjem delu hrbtenice po enem letu nekoliko povečala in po dveh letih še nekoliko več.
  • Samo ena študija, 53 moških in 53 žensk, je preučevala zlome in v 12 mesecih ni našla nobenega.
  • Samo ena študija je zajela najstnike, ki so dobili zaviralce pubertete in nato hormone, in ugotovila, da so imeli moški pri 22 letih nižjo gostoto kosti hrbtenice kot pred zdravljenjem.
  • Avtorji so rekli, da je večina dokazov izhajala iz študij z zmernim tveganjem zavajanja in da je učinek na tveganje zlomov negotov.
  • Pregled je bil narejen za Endocrine Society, z načrtom, pripravljenim z njenimi strokovnjaki, v podporo njenim smernicam iz leta 2017.

Abstract

BACKGROUND: The impact of sex steroids on bone health in transgender individuals is unclear.

METHODS: A comprehensive search of several databases to 7 April 2015 was conducted for studies evaluating bone health in transgender individuals receiving sex steroids. Pairs of reviewers selected and appraised studies. A random effects model was used to pool weighted mean differences and 95% confidence intervals (CIs).

RESULTS: Thirteen studies evaluating 639 transgender individuals were identified [392 male-to-female (MTF), 247 female-to-male (FTM)]. In FTM individuals and compared with baseline values before initiation of masculinizing hormone therapy, there was no statistically significant difference in the lumbar spine, femoral neck, or total hip bone mineral density (BMD) when assessed at 12 and 24 months. In MTF individuals and compared with baseline values before initiation of feminizing hormone therapy, there was a statistically significant increase in lumbar spine BMD at 12 months (0.04 g/cm2; 95% CI, 0.03 to 0.06 g/cm2) and 24 months (0.06 g/cm2; 95% CI, 0.04 to 0.08 g/cm2). Fracture rates were evaluated in a single cohort of 53 MTF and 53 FTM individuals, with no events at 12 months. The body of evidence is derived mostly from observational studies at moderate risk of bias.

CONCLUSION: In FTM individuals, masculinizing hormone therapy was not associated with significant changes in BMD, whereas in MTF individuals feminizing hormone therapy was associated with an increase in BMD at the lumbar spine. The impact of these BMD changes on patient-important outcomes such as fracture risk is uncertain.

Conclusion

In FTM individuals, masculinizing hormone therapy was not associated with significant changes in BMD, whereas in MTF individuals feminizing hormone therapy was associated with an increase in BMD at the lumbar spine. The impact of these BMD changes on patient-important outcomes such as fracture risk is uncertain.