Rút lại: Nghiên cứu Na Uy báo cáo 18 trường hợp chuyển đổi giới tính ngược lại sau khi dùng Testosterone và 22% được xuất viện mà không được điều trị y tế

Các quỹ đạo điều trị trong số trẻ em và thanh thiếu niên được giới thiệu đến Trung tâm Quốc gia Na Uy về Không phù hợp Giới tính

Nghiên cứu thuần tập & sổ bộ Chuyển giới trở lại & hối tiếc Liệu pháp hormone chéo giới

Authors: Cecilie Bjertness Nyquist, Leila Torgersen, Linda W. David, Trond Haaken Diseth, Kjersti Gulbrandsen, Anne Waehre
Journal: Acta Paediatrica
Year: 2025
Source: pubmed.ncbi.nlm.nih.gov/39648282/

Summary

Clinicians at Norway's national gender service used its own records to trace every child and teenager referred over 20 years. Of 1,258 referred, 62% went on to cross-sex hormones. Nearly all of the 11% given puberty blockers (97%) moved on to hormones. 22% of those who attended left without any medical treatment. Eighteen females stopped testosterone and detransitioned, and 11 people in the group died, though causes of death were not recorded. The authors admit the detransition count is probably too low, because people who stop often drop out of the clinic's sight. In July 2026 the journal withdrew (retracted) the paper after a research-integrity panel found it lacked ethics committee approval and patient consent. Five authors were found to have committed misconduct, which they are appealing. Its figures should not be quoted as settled evidence.

Key findings

Tạp chí đã rút lại bài báo vào tháng 7 năm 2026 vì nghiên cứu thiếu sự chấp thuận của ủy ban đạo đức nghiên cứu y học Na Uy và sự đồng ý đúng mức từ bệnh nhân. Việc rút lại không chỉ ra lỗi trong dữ liệu.
Trong 1.258 trẻ em và thanh thiếu niên được giới thiệu từ năm 2000 đến 2020, 861 người (68,4%) sinh ra là nữ, và tuổi trung bình khi được giới thiệu là 14,4.
135 người (10,7%) bắt đầu dùng thuốc chặn dậy thì, thường là những người sinh ra là nam, và 97% trong số đó tiếp tục dùng hormone khác giới.
783 người (62,2%) trong tất cả những người được giới thiệu bắt đầu dùng hormone khác giới.
264 trong 1.198 người đã đến ít nhất một cuộc hẹn (22,0%) đã rời phòng khám mà không điều trị y tế nào liên quan đến giới.
Tất cả 18 người được ghi nhận là ngừng hormone (2,3% trong 783 người bắt đầu) đều sinh ra là nữ và bắt đầu dùng testosterone từ năm 2015 đến 2021. 11 người không còn thấy mình là người chuyển giới; 7 người vẫn thấy vậy (5 người hài lòng với những thay đổi họ có, 2 người lo lắng về khả năng sinh sản).
Mười một trong 1.258 người (0,9%) đã qua đời vào cuối năm 2023; nguyên nhân tử vong không có sẵn.

Abstract

Aim: We aimed to describe treatment trajectories, detransition and mortality rate among children and adolescents referred to the Norwegian National Center for Gender Incongruence (NCGI). Methods: The cohort included all 1258 persons under 18 years at referral to the NCGI from 2000 to 2020. Trajectories were registered until end of 2023. Results: In total, 861/1258 (68.4%) were assigned female gender at birth (AFAB). Mean age at referral was 14.4 years. Puberty suppression with gonadotropin-releasing hormone agonists (GnRHa) was initiated among 135/1258 (10.7%), significantly more persons assigned male gender at birth (AMAB) than AFAB (p < 0.001). Gender-affirming hormonal treatment (GAHT) was initiated in 783/1258 (62.2%). The continuation rate from GnRHa to GAHT was 97%. Discharge rate from NCGI without gender-affirming medical treatment among those who attended at least one appointment, was 264/1198 (22.0%). Eighteen AFAB detransitioned after initiated GAHT, eleven due to a cessation of transgender identity. Mortality rate in the cohort until end of 2023 was 11/1258 (0.9%). Conclusion: Different trajectories including medical pathways and assessments without gender-affirming treatment were observed. GAHT was initiated in 783/1258 (62.2%), including eighteen AFAB detransitioning after testosterone treatment. There was a high continuation rate from GnRHa to GAHT. Various trajectories highlights the need for long-term follow-up in care.

Conclusion

This study provides valuable insights to gender-affirming care for children and adolescents, owing to its large sample size, including all children and adolescents referred to a national gender clinic over two decades. The study reports varying trajectories, encompassing both medical pathways and assessments ended without gender-affirming medical treatment. Our findings highlight the necessity for long-term follow-up and support of people referred to gender clinics. There is a need for ongoing research on gender-affirming treatment in young people to evaluate the short- and long-term benefits and risks of early treatment interventions, as well as patient-reported outcome measures.

Methodological limitations

Retracted for ethics breaches: The journal withdrew the article on 30 July 2026 after a research-integrity panel from Oslo University Hospital, Akershus University Hospital and the University of Oslo found it lacked approval from a regional ethics committee and proper consent. Five Oslo-based authors were found to have committed misconduct and are appealing (Retraction Watch, September 2026). The problem is ethics, not known data errors.
Records filled in afterwards: The data came from a clinic register built by going back through patient files, so some information may be missing, as the authors say.
Treatment elsewhere missed: Treatment from other providers was recorded only if clinic staff were told and wrote it down. People who treated themselves or got treatment privately or abroad were missed.
Detransition likely undercounted: People who stop treatment may stop coming to the clinic, and what happened after discharge was often unknown. So 18 detransitions (2.3%) is a minimum. The authors point to a Finnish study where 7.9% stopped, for comparison.
Uneven, often short follow-up: Referrals ran to 2020 and tracking to 2023, so follow-up ranged from about 3 to over 20 years. Recent referrals had little time to start or stop treatment, and the authors say recent percentages cannot be interpreted.
Rules changed over time: The criteria for treatment changed over two decades, so the combined rates mix very different eras of practice.
No information on when it began: The study could not separate gender distress that began in childhood from distress that began in the teens, which may matter for later desistance (no longer having gender distress).
Too few cases to draw conclusions: The authors say the detransition numbers are too small to draw any conclusions. All 18 were born female, and detransition was only counted when a stop in hormones was recorded.
Causes of death missing: Deaths came from the national register without causes, so the 0.9% death rate, including any suicides, cannot be interpreted.
Already filtered by referral: All young people were referred by local child mental health clinics after a first assessment. This may favour more severe cases and limits how far results apply to young people never referred.
No patients' own views: The study recorded treatment steps only, with no measures of gender distress, mental health, quality of life or satisfaction.
Clinic judging itself: The authors were clinicians and researchers at the national clinic whose practice is described. One author (Waehre) declared she had been an outside reviewer for Sweden's 2020–2022 national evidence review on gender dysphoria.

detrans.ai

Summary

Key findings

Abstract

Conclusion